Sentence examples for functional cooperativity in the regulation of from inspiring English sources

These in vivo results corroborate our in vitro findings and highlight the significance of PAK4/MMP-2 funcooperativityratinithein the regulation of αv β3/EGFR survival signaling in glioma.

In general, to obtain bistability a gene circuit must have positive feedback and cooperativity in the regulation of gene expression.

In our previous study, we demonstrated a functional role for PARP1 in the regulation of pre-mRNA splicing7.

Our results highlight the functional cooperativity between PAK4 and MMP-2 by direct interaction in the regulation of anoikis resistance and metastases, and thereby provide a biological basis for potential future therapeutic significance of dual targeting of PAK4 and MMP-2 in the glioma treatment.

Samuels, E. R. & Szabadi, E. Functional neuroanatomy of the noradrenergic locus coeruleus: its roles in the regulation of arousal and autonomic function part I: principles of functional organisation.

Additionally, although it is thought that DnaK does not function alone and always acts in concert with co-chaperones in the regulation of proteostasis, it is not known whether this cooperativity is required for certain cellular processes.

Interestingly, the metabolic model revealed that the regulation of photosynthetic activity in Synechocystis sp. is rather complex and a high degree of cooperativity between nine alternative electron flow pathways is important for optimal photoautotrophic metabolism [ 82].

Importantly, it reveals the CaM specific type of cooperativity involved in this process and helps to explain the contribution of cooperativity in the specificity of CaM-dependent regulation.

In the 1960's, Dan Koshland introduced the idea of "negative cooperativity" in the function of proteins with multiple subunits.

This process enables cooperativity in the production of specialized functional units within a cell such as muscle fibre structures, mitochondria and metabolic circuits.

In chemistry, Hopfield offered an explanation of the role of cooperativity in the binding of oxygen atoms to hemoglobin.