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These findings demonstrate important functional contributions from both symmetric and asymmetric Hsp90 dimers and provide valuable reagents for future investigations of Hsp90 mechanism.
Measuring the degree of transposon remobilization and selection for maintenance of footprints in tumors is important to ensure that functional contributions from these events are not missed when interpreting data from SB insertional mutagenesis screens.
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The cell to cell movement of viruses is a complex and dynamic process which involves functional contribution from many proteins of viral and host origin [2].
Recently, a significant number of functional retrocopies (i.e. retrogenes) have been identified in the genomes of mammals and insects [9], [10], [11], [12],, which raised the interest in studying the functional contribution from retroposition.
We previously showed that HcDPPIVB is the gene responsible for the majority of secreted DppIV activity in H. capsulatum culture supernatant, while we could not detect any functional contribution from HcDPPIVA.
Finally, it describes actual or potential functional contributions arising from reversible formations and cleavages of Si−H, Si−C and other bonds at the pincer frameworks.
Thus the same genes that regulate EMT in epithelial cancer cells also regulate functional contributions to malignant progression from the tumor stroma.
Successful utilization of quantitative and systems pharmacology (concepts, models, resources) in drug discovery requires a change from discrete functional contributions to a crossfunctional integration of knowledge in discovery project teams.
To determine their independent functional contributions of CD28 and NKG2D, we sorted the total CD3+CD8+ T cells from human PBMC and stimulated them with plate-bound anti-CD3, anti-CD28 and anti-NKG2D mAb alone or in combinations.
Furthermore, analysis of ZO-1 and ZONAB in human tissues derived from patients with different retinopathies will help to elucidate the functional contributions of this TJ-associated signalling pathway in retinal physiology and pathology.
Therefore based on the sequence and structural homology of the modeled mycobacterial CoaE, we chose residues from all the three domains of the mycobacterial CoaE to identify their functional contributions.
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