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As rs78378222 changes the polyadenylation signal of TP53 leading to impaired 3′-end processing of TP53 mRNA, the SNP has strong plausibility for being directly functional contributing to the aetiological basis of glioma.
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For the polymorphic population, all mutants that were functional contributed an equal amount of plasmid DNA as template for the next generation.
In addition, TMZ resistance frequently develops due to efficient repair of toxic O6-methylguanine adducts or due to defects in the MMR, which, when functional, contributes to TMZ cell killing.
The chapter concerns approaches and challenges in designing self-repairing functional coatings, contributing to development of new functional materials and coatings.
This is due to part of the doped nitrogen atoms act as functional groups, contributing to the total concentration of functional groups.
However, in composite electrolytes, the fillers are usually rigid inorganic nanoparticles with limited functional groups contributing to mechanical properties and/or adhesion properties.
Older age is associated with higher prevalence of chronic illness and functional impairment, contributing to an increased rate of hospitalization and admission to Intensive Care Units.
Underlying functional haplotypes contributing to disease vulnerability may be tagged differently by different SNP sets in different samples.
Thoroughbred horses have been selected for exceptional racing performance resulting in system-wide structural and functional adaptations contributing to elite athletic phenotypes.
This further suggests that there is more than one functional allele contributing to schizophrenia susceptibility in the DAOA/G72 region.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com