At the same time, the AsPCS inter-regional lack of correlations point to local functional constriction divergences, particularly in the E6 and LCR regions (Table 2).
In particular, maxillary constriction and functional unilateral posterior crossbite have been shown to be associated with temporomandibular disorders and altered muscle function.
Conversely, PripL, which represents the smallest aquaporin in the louse superfamily with 258 amino acids and a predicted molecular mass of 27.8 kD, displays the more canonical ar/R constriction and functional (P1 P5) residues associated with the water-selective branch of aquaporins (Fig. 1a, c) [ 7, 50].
Maxillary transverse deficiency might cause functional interferences, and removing maxillary constriction might lead to Class II spontaneous improvement.
Bronchial hyperresponsiveness (BHR), the key feature of asthma, is a functional abnormality in which airway constriction is triggered by environmental stimuli that otherwise do not affect healthy individuals.
The use of the long alkyl, aryl, phenylene, polyethylene glycol, or heterocyclic chain allows the indomethacin functionality to fully insert into the binding pocket of COX-2, while the bulky fluorescent secondary amide functional group projects through the constriction at the base of the active site and into the wide lobby in the membrane-binding domain.
How these heterogeneous constriction patterns lead to functional impairment in asthma have only been recently explored using computational airway tree models.
This indicated to us that the extra constrictions and division sites were functional in the sense that they led to complete cell separation (abscission).
Hyperoxia, as applied during the treatment of sepsis with high levels of inspired oxygen, or during cardiopulmonary bypass in CABG surgery, can lead to arteriolar constriction, causing a reduction in functional capillary density and distributive microcirculatory alterations [ 45].
