Exact(1)
Since this observation suggested that cytoplasmic translocation of FIH-1 from the nucleus abrogated the antagonistic effect of FIH-1, we examined the relationship among potentially functional (conserving nuclear expression) and nonfunctional (no nuclear expression) FIH-1 and survival.
Similar(59)
We would expect coding sequences to be conserved, but regions of non-coding conservation, which could harbour potential functional (conserved) sequences, are of particular interest.
SAP domains occur in a multitude of DNA binding proteins that contain a diverse set of other functional conserved domains.
Based on the results of mutants synapse and cleavage analysis, we have found more functional conserved residuals in the N-terminus of phiC31 integrase.
CNetA also finds more functional conserved matching pairs based on GO coverage and SGO.
Finally, a strong evidence of negative selection implies that these substitutions are occurring in functional, conserved sequences.
Although both metabolic pathways may be considered ancient and were classified as functional conserved in this study, the patterns of functional similarities are different and may reflect the constraints of enzyme recruitment and the ubiquity of some types of compounds.
These results indicate that the iterative bi-directional mapping strategy is not only useful to identify one-to-one mappings, but also helpful to reveal more functional conserved alignments.
These findings suggest that (i) the ancestral sarcopterygian AMTN exon 7 possessed this SxxE motif, (ii) the motif is functional (conserved during more than 430 Ma), and (iii) AMTN exon 7 is homologous to AMBN exon 12 and to ENAM exon 8, all of them preceding the large exons 8, 13 and 10, respectively.
Comparative analysis indicated that 12 rhizome-specific expressed genes on the rhizome-related QTL intervals of O. longistaminata were aligned with similar genes in the sorghum genome, suggesting that functional conserved candidate genes across taxa could account for rhizome growth and development.
This subset of sequences was named the Metabolic Map Functional Conserved Dataset (MMFCD).
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