Overall, our data highlight that whereas EZH2 and BMI1 may function in a 'linear' pathway in normal development, their overexpression has different functional consequences for breast tumourigenesis.
Functional consequences for glioma of protease inhibition in situ and in vitro.
Here I review the factors that influence NK cell repertoire diversity and its functional consequences for our ability to fight viruses.
For HIV-1, GWAS demonstrate that some naturally selected variants in the host-pathogen protein interaction networks continue to have functional consequences for susceptibility to these pathogens.
Because of their ubiquity and mobility, arthropods can serve as important agents of movement for microbiota15,16, but they also make up a diverse indoor community themselves5, with many species having functional consequences for homes, humans, or pets17.
We have discovered a systematic bias in the automated variant effect prediction at the RMA loci, as well as widespread switching of functional consequences for variants located in the same codon as the RMA.
We seek to determine the functional consequences for these amino acid differences and determine whether such information can be used to design high potency antagonists and agonists.
Our results suggest that even small emotion perception impairments can have negative functional consequences for individuals with BD.
Thus, alterations in the subunit composition of PP2A holoenzymes have significant functional consequences for the initiation of in vitro SV40 DNA replication.
To elucidate functional consequences for viral replication and PI susceptibility by changes in Gag that evolve in vivo during PI therapy, a panel of recombinant viruses was constructed.
Here, we provide an overview of the types of genetic changes commonly observed in hPSC cultures and their functional consequences for hPSC phenotype and behavior.
