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GBC is designed to identify brain regions having maximal functional connectedness with the rest of the brain, and alterations in GBC may reflect a restriction or broadening of network synchronization.
The positive correlation between functional connectedness of the motor network and disease progression rate could suggest spread of disease along functional connections of the motor network.
Overall functional organisation of the motor network was unchanged in patients with ALS compared to healthy controls, however the level of functional connectedness was significantly correlated with disease progression rate.
Long-distance synchronization, as an approximation of functional connectedness, is quantified by the assessment of the statistical interdependency between time series (for which EEG next to fMRI and magnetoencephalography (MEG) is used) [ 31].
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In this algorithm, two kinds of local spatial attractions are considered in the functional form of membership connectedness and the required seeds can be selected automatically.
Budd refers to differences in response to selection caused by differences in the degree of connectedness as functional asymmetry and suggests that this asymmetry introduces evolutionary flexibility into the system.
However, in SES, the effects of "1 + 1 > 2" and "1 + 1 < 2" are also observed, which suggests that which two nodes are connected may be more important than the connection itself, and therefore our research focus may need to be shifted from structural connectedness to functional integration.
Our findings show that in the patients with mTLE, the local connectedness of the brain functional network is relatively sparse and is poorly fault tolerant in the case of loss of connectivity.
All subscales, except for connectedness with nature, were related with the Functional Assessment of Chronic Illness Therapy – Spiritual Well-Being Scale.
However, the connectedness levels for lowly heritable traits, e.g. functional traits, were still poor.
Organisational functional connectivity characteristics (the number of connections and level of local connectedness gamma) were compared between ALS patients and healthy controls using GLM statistics, controlling for possible effects of age.
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