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Functional confirmation of non-coding function on a broader array of candidate NC-RNAs and a systematic approach to NC-RNA interaction discovery will likely enhance our understanding of the NC-interactome functions in pathological and physiological conditions.
We report molecular modeling and functional confirmation of Ole and HT binding to HIV-1 integrase.
Reversion of the established mutation, also referred as rescue experiments, is critical for functional confirmation of targeted genes.
The QTL mapping result and variation distributions are expected to make candidate fixing and further functional confirmation easy.
Bioinformatic mining of the data and functional confirmation remains an important challenge and is one of the exciting areas of progress.
Functional confirmation of the relevance of these results for osteoblast morphological transitions came from experiments in which Shh hedgehog signalling was inhibited using the well-established pathway inhibitor cyclopamine (Cyc).
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The core of the BAG domain comprises two anti-parallel alpha-helices that mediate interaction with the HSC70 and HSP70 heat shock proteins (Briknarova et al, 2001; Sondermann et al, 2001), molecular chaperones that bind proteins in non-native states assisting them to reach functional confirmations.
Results obtained from rodent studies are useful but, due to the anatomical, molecular and functional differences, confirmation of these findings in large animals or non-human primates may lead to basic discoveries that cannot be made in rodent models and that are more useful for developing treatment strategies in humans.
In past years, when the Senate was a more functional body, confirmation votes for district court nominees were regularly held by unanimous consent or voice vote, taking a few seconds or minutes at most.
The letters are written based on the functional group confirmation of the particular compound.
When CaV1.2-VN and CaV1.2-VC are brought close enough together to interact, the full Venus protein can fold into its functional, fluorescent confirmation.
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