Sentence examples for functional cones from inspiring English sources

In addition, it has been stated that keeping the functional cones alive, may potentially prevent 1.5 million people worldwide from becoming blind [40].

Mice possessing functional rods but lacking functional cones and ipRGCs show an OKR only at scotopic light levels (Figure 3A, line 3), whereas mice possessing functional cones but lacking functional rods or ipRGCs show an OKR only at photopic light levels (Figure 3A, line 4).

We measured the b-wave amplitude of ERGs, representative of ON (response to light stimulus onset) bipolar cell activity, to assess the integrative response of functional cones.

In 3 (out of 4) subjects, representing typical oligocone trichromacy, a uniform reduction in cone density was identified, in combination with a reduced outer nuclear layer thickness on spectral-domain optical coherence tomography; these findings support the original hypothesis that oligocone trichromacy is characterized by a reduced number of functional cones.

In spite of variation in nanoparticle-driven gene expression in cones, we observed essentially complete functional cone recovery (to WT levels) in many IRBP-NMP treated animals.

Moreover the rod function loss occuring prior to the gene transfer could also have a deleterious effect on the cone and rod environment (less neurotrophic support, release of toxic agents, etc). in the more stable Rpe65R91W/R91W Gnat1-/ model, thus preventing functional cone rescue.

Finally, as we observed a limited effect with the early treatment of Rpe65-/ Rho-/ mice compared to the study of Pang et al. (2010) [18], we may also have to improve our protocol in order to increase the dose of RPE65 re-expression to allow a functional cone recovery in these models.

By just studying the cone mosaic, we are unable to assess the functional aspect of a visible cone and correlate whether a visible cone is a functional cone.

Ninety-seven percent of fish examined in this study employed cone subsets of four or five pigments, with most M. auratus and P. taeniolatus exhibiting five functional cone classes.

To quantify the number of physiologically functional cone classes, we recorded electroretinograms (ERG) from whole fish preparations of three Malawi cichlids: Metriaclima zebra, Melanochromis auratus and Protomelas taeniolatus.

Although the surface of the eye appeared very irregular by scanning electron microscopy, microscopic sections confirmed the presence of relatively normal lenses, implying the presence of functional cone and pigment cells.