Exact(5)
The POT score proposed in this paper considers the functional concordance between signature hubs only according to their overlapping neighbours.
The (P-POD) [ 26] was used to identify homologous genes [ 27], yielding many examples of functional concordance between biogenesis factors for Yor1-ΔF and those known for CFTR-ΔF.
We employed profile HMMs from the Protein Families Database A (PfamA) (Punta et al. 2012) and HMMER3 (Eddy 2011) to ascertain putative functional concordance between proposed orthologs and the human consensus coding sequences of interest.
The clustering and gene ontology results showed excellent functional concordance between mRNA and miRNA, demonstrating the significant involvement of neuronal cellular components and biological processes such as: signal transduction, transcriptional regulation, metabolism, response to stimuli, cell cycle/apoptosis, protein modification, neuronal processes and ion transport, respectively.
Although limited direct comparison of primary breast tumor tissue and corresponding short-term cultures has assisted in authenticating the malignant origin of tumor-derived cultures [ 1- 3, 9], relatively little is known regarding the degree of phenotypic and functional concordance between malignant epithelial populations in human breast tissue and their counterparts in vitro.
Similar(55)
Thus, despite the many differences in experimental designs between studies, this in silico validation indicates that there is significant and previously unappreciated concordance between functional genomic studies related to AD.
Furthermore, while we do not know the functional importance of the sites, concordance between selection analyses in both birds and mammals suggests that special attention should be paid to positions 244 246, 273 275, 301 in TLR4 and 293, 294, 314, 342, 422, 525, 532, 533 in TLR5.
Seventy-eight of the 118 IPF prognostic predictor genes (66%%) was functionally connected in these five gene networks, supporting a concordance between expression correlations and functional connections of individual genes.
Such a lack of spatial concordance between morphological and functional signal would in turn lead to uncontrollable errors of the PVE correction.
We might, however, expect greater concordance between populations if aberrant functional modules of genes were compared.
The parameters E 1, α 1, α 2, γL and T g were defined from the better concordance between the experimental and numerical results by minimizing the functional discrepancy.
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