As a novel therapeutic approach in complement-mediated pathologies, we recently developed a human C3 derivative capable of obliterating functional complement by a catalytic, non-inhibitory mechanism.
Multiple innate inflammatory responses induced after systemic adenovirus vector delivery depend on a functional complement system.
Rather, the social investment approach focuses on the functional complement between welfare and market, the public and the private.
Indeed, tolerance serves as the functional complement to immune destruction, inasmuch as each modality plays an essential role in mediating the organism's relationship to its world.
Pairwise or multiple comparisons between metagenomes can be made at the level of sequence composition (comparing GC-content or genome size), taxonomic diversity, or functional complement.
Naturally occurring deficiencies of specific complement components highlight the need for a fully functional complement system.
Binding of Ficolins on acBSA was evaluated, as was functional complement activation assessed by C4, C3 and terminal complement complex (TCC) deposition.
C4BP positivity extends beyond the area positive for C3b, which suggests that C4BP is a functional complement inhibitor in AMI and limits complement activation to the most affected tissue.
Since functional complement proteins are present in the bronchoalveolar lavage fluid (BALF) [20], complement C3-dependent opsonization is expected to play an important role in the early stages of inhalational B. anthracis infection.
