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Representative pictures of functional collagen of lung metastases tissue based on picro-Sirius red staining and polarized light microscopy.
Extended Data Fig. 8 Functional collagen deposition decreases in the lung metastatic niche upon pyruvate metabolism inhibition.
It is concluded that real, functional collagen engineering is a pivotal target and that we are far more advanced in our progress than is commonly understood.
These are functional collagen receptors, whose tyrosine kinase is activated upon binding to collagen.
Yet another approach to limit the production of "functional" collagen molecules was to administer proline analogues [ 26].
Stimulation of MCs with collagen induced tyrosine phosphorylation of DDR1, indicating that mesangial DDR1 is a functional collagen receptor.
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These cells lack functional collagen-binding β1 integrins.
Because proline is a major residue in fibrillar collagens and constitutes ~10% of the total pool of collagen amino acid residues, the rationale behind this concept was that incorporating proline analogues to newly synthesized collagen chains, instead of native proline residues, would lead to the formation of non-functional collagen molecules.
We genetically engineered M13 phages with two functional peptides, collagen mimetic peptide and streptavidin binding peptide, on their minor and major coat proteins, respectively.
Actomyosin is the major contractile protein complex and is, therefore, an index of functional muscle; collagen is the major protein of connective and scar tissue and is, therefore, an index of fibrosis.
Functional Foods: collagen, live probiotics and ashwagandha.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com