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According to the ontological characterization of AHRE-II-regulated genes, XRE-regulated, AnoC-regulated [ 43] and AHRE-II-regulated genes showed strong functional coherence with significant enrichment in ion channels and transporters, unlike XRE-regulated genes [ 43].
The reduction in connectivity from the thalamus to the SMA/premotor region indicates a structural alteration of the thalamo cortical motor control circuit as described by Alexander and Crutcher (1990) and that the thalamic region is involved in abnormal and increased cognition-modulated functional coherence with anterior frontal and premotor cortex.
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Although SPI can identify growth inhibitory cDNAs, there is little reason to expect functional coherence within this group since interference with many functions can be detrimental.
Most clusters (26/29) had enriched functional classes according to the criteria, indicating their functional coherence within each cluster (Table 2).
We can see in Figure 5 that PBNA and C_PBNA have very similar functional coherence values with only a few minor differences.
The main goal of this study was to introduce functional coherence metrics with high levels of discriminative power, based on the currently available GO annotations.
Precision again correlates with the functional coherence of CCS and with the number of compared species, but the impact is less pronounced.
We show that using functional similarity to map proteins across species improves network alignment in terms of functional coherence and overlap with experimentally verified protein complexes.
This increased overage does not affect the module quality as both the functional coherence and overlap with MIPS complexes is still better than sequence-based alignment methods.
To further investigate the results, we assessed how well the graph-based functional coherence evaluations agree with a metric commonly used to measure similarity of profiles within a cluster the silhouette index (Rousseeuw, 1987).
Furthermore, < k rs > was devised so that both aspects of functional coherence can be evaluated with a unified metric.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com