We did not observe any cluster regrouping RSR sequences with a similar function ("functional cluster").
Two genomic structural characteristics were measured: the propensity of adjacent genes to be clustered on the same strand (using the sidedness index Cs) and the clustering of functionally related genes (using the functional cluster index, Cf) (see Methods).
GO term enrichment for biological functions was performed as previously reported [46], in order to determine whether the observed inter-group variations affected a functional cluster of proteins sharing similar biological and molecular functions, or co-localizing in a sub-cellular compartment.
The second functional cluster of expression changes observed relates to immune function, with a concerted downregulation of MHC genes (predominantly class I genes, but also some class Ib and class II genes) and the Tap2 peptide transporter necessary for antigen presentation by class I molecules.
So the only enriched functional cluster for this module contained genes implicated in cilium function (Table 3).
When functionally analyzed, most genes connecting two QTLs could be included in a single functional cluster.
In solanum, TPS form functional cluster with cis-prenyl transferase (Matsuba et al. 2013).
CIS also detects the conventional functional clusters in the whole brain neural network (e.g., the visual cluster, the motor cluster, the frontal cluster, etc)., as well as meaningful overlaps, and also revealed the possible existence of an emotional memory functional cluster.
Briefly, the activity of each neuron in the model represents the activity of a certain functional cluster of neurons.
Of these genes, one functional cluster was identified, and this cluster (Darpp-32, Drd1a, and Rgs9) is an established modulator of dopamine signaling.
To obtain a more synthetic annotation, the enriched nodes directly connected by a path in the GO graph were grouped together in the same functional cluster.
