Sentence examples for functional clock from inspiring English sources
We chose to use cultured third-instar larval brains for live imaging, as larval circadian circuits are numerically simpler yet composed of fully differentiated and functional clock neurons35.
These results show that even at the age of 2 days, most bees have a functional clock that can be entrained by time-givers in the hive.
While we did not accomplish the ambitious goal of creating an internet connected centralized display this semester, we did build a self contained and novel device that works as functional clock.
It is worth noting that only few of all circadian transcripts in the liver remain rhythmically expressed in absence of a functional clock in hepatocytes [10].
Preliminary work in our lab supports that mammary tissue in fact possesses a functional clock that can be reset by external signals.
In the case of flies doubly-mutant for PDF and CRY signaling pathways, their loss of strong rhythmic behavior in LD conditions suggests that these double mutant flies have lost functional clock and/or light entrainment.
In this study, we address this issue by generating transgenic Xenopus that lack functional clocks specifically in either rod or cone photoreceptor cells.
The difference between Clock mutation and Clock gene disruption (knockout) is that with Clock mutation, the non-functional CLOCK protein may compete with NPAS2 for interaction with BMAL1, producing a transcriptionally inactive complex [ 20- 22].
Most recently, an RNAi screen in Drosophila revealed that genes involved in Fe metabolism were important for a functional circadian clock, while a role for haem in the fly clock was not immediately clear (Mandilaras and Missirlis, 2012).
If there is consistently no functional circadian clock in both RNAi treatments, then phenotypic differences between those treatments cannot be ascribed to the circadian clock.
The discovery of a functional circadian clock in articular cartilage, and that it declines during aging, opens up the possibility of targeting the clock to ameliorate age-related changes (and perhaps in OA-susceptibility).
