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Functional classes were investigated to search for groups of genes with A/ S ratios that were statistically above (highest) or below (lowest) the overall distribution of A/ S ratios.
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Interactions between region and animal class, year and animal class, as well as season and animal class were investigated.
Another allosteric PI class being investigated are dimerization inhibitors.
Representative genes belonging to these functional classes are described below.
Divisions into broad functional classes are shown in Figure 4.
Both of these functional classes are typical for cancer genes.
We observe that most of the expected functional classes are present among our 50 classes.
Global bounds for Jensen's functional were investigated in [7].
The changes in WHO functional class were not statistically significant.
Associations with WHO functional class were calculated using ANOVA.
While changes in 6MWD, NT-proBNP, and WHO functional class are well-established measures of PAH treatment efficacy, questionnaire-based analysis of QoL and treatment satisfaction following a switch in therapy have not been extensively investigated 18– 20.
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