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Our analysis shows that this pattern of EV reflects functional centrality: proteins with highly specific signaling functions are modulated more frequently than those with highly central functions in the network, which is also consistent with previous studies on tissue-specific gene expression.
We argue that functional centrality, namely the extent to which a functional department is central in the intra-organizational network, affects employees' innovation intensity.
It contained the kitchen, the photocopier and printers, and key reference materials, and this functional centrality also drove traffic.
In fact, physical centrality is often less important than "functional centrality"—proximity to such things as entrances, restrooms, stairwells, elevators, photocopiers, coffee machines, and, of course, the watercooler.
Correspondingly, this concept provides a characterization of the robustness and functional centrality for each enzyme involved in a given metabolic network.
Despite the functional centrality of these transitions in multicellular organisms, it has remained challenging to determine which transitions occur and at what rates without perturbations and cell engineering.
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We used this functional degree centrality to determine robustness of the network.
Lacking existing counts of cyclists and pedestrians, we chose count sites based on street functional class and centrality (a measure of trip potential).
As well-known, weighted protein interaction network can be constructed by integrating functional annotations, and centrality is also can be extended to weighted network easily [ 20].
Therefore, the cancer gene set also had the functional and topological centrality in complex biological networks and played the critical role in the development of diseases.
Compared with previous results by functional enrichment analysis, graph centralities, especially the eigenvector centrality and subgraph centrality, based gene signatures are more tightly related to breast cancer.
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