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From the best available evidence it appears that at MMR all five of the major steps in energy delivery (namely, ventilation, pulmonary diffusion, cardiac output, tissue capillary – mitochondrial O2 transfer, and aerobic cell metabolism per se) approach an upper functional ceiling, with control strength being distributed amongst the various O2 flux steps.
On the energy demand side, the situation is somewhat simplified since at MMR approximately 90% of O2-based ATP synthesis is used for actomyosin (AM) and Ca2+ ATPases; at MMR these two ATP demand rates also appear to be near an upper functional ceiling.
While indie games partly deal with this issue, the reduced budgets do generally limit their functional scope, again reaching a functional ceiling and limiting their market influence.
The "functional ceiling" was proposed due to the number of opportunities available for individuals to reach peak cognitive performance, including daily demands such as inhibiting distractions and unsuitable responses (Bialystok, Craik, & Luk, 2012).
These additive effects on mechanical performance (slowed relaxation and Ca2+ decay) show evidence of a functional ceiling for some mutant combinations suggesting there are limits to mechanical dysfunction induced by compound mutations.
The model incorporates functional ceiling effects obtained by combining two strong activator alleles (or two strong deactivating alleles) where the myofilament activation (or deactivaiton) reaches a functional threshold and is no longer additive on a one to one basis.
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The lack of potentiating effects cannot be attributed to the use of an amphetamine dose producing "ceiling" functional effects, as region-specific potentiation of response by different pharmacological mechanisms has been previously described using the same protocol and dose of D-amphetamine [18], [20].
Production designer Richard Hoover has explained that the sound stages were constructed with ceilings and functional hallways an unusual practice for television production allowing actors to be filmed entering a scene without cuts.
However, the isolation of these clones would not have been possible without the exploitation of SecYEG-mediated quality control as a screening platform; rather, we would have remained stalled at the self-imposed 'glass-ceiling' of functional advantage.
Here, ⌈.⌉ denotes the ceiling function.
where ⌈·⌉ represents the ceiling function.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com