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Given the potential for functional burden that ADHD may place on children and adolescents, an improvement in functioning in these areas is of great value both to patients and their caregivers [ 17].
It also has the advantage of having been used in several studies of SE, and it is well suited to an assessment of the physical and functional burden after CSE [43].
Limited, but consistent, research indicates that patients with AL amyloidosis experience substantial functional burden due to their condition, including significant deficits in both physical and mental aspects of HRQoL, diminished life satisfaction, and greater levels of anxiety and depression [7, 8, 9, 10, 11, 12, 13, 14].
OA imposes a significant functional burden on affected individuals.
Irrespective of its long history, the gene fusion seems to impose a functional burden on the encoded gene products.
Furthermore, there is often a substantial psychosocial and functional burden associated with undiagnosed and untreated ADHD [ 14].
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The high prevalence of functional burdens in our population is probably partly caused by a referral bias because our center is a tertiary referral center for RP and general rhinology.
After correction for multiple hypothesis testing, InVEx identified only PTCH1 (Patched 1) as having a significant functional mutation burden.
8 We demonstrated, using RT3DE, that the functional LA burden observed in OSA could be, at least partially, reversed after effective long-term CPAP therapy.
Disadvantages resulting from limited education may contribute to the greater physical disability and functional limitation burden experienced by our older women.
Also, data on premorbid functional status, burden of comorbid illness, and the presence/nature of early mobility or ICU-based rehabilitation programs or other relevant ICU-based practice patterns, including exposure to corticosteroids [ 19] and paralytics [ 20], in this study sample would have been very helpful to further inform risk, risk modifiers, and rehabilitation potential.
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