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A somewhat functional blueprint may be under their noses in the form of the stress tests just completed on the 19 largest financial institutions.
Efforts to elucidate the interaction network of all proteins within a cell or organism — termed the interactome — has helped identify the architectural and functional blueprint of cellular processes in various model eukaryotic organisms, such as yeast [1] [5], Drosophila [6] [9], C. elegans [10] [14], Plasmodium [15], Arabidopsis [16] [17], mouse [18] and humans [19] [22].
Thus, ePGBDs provide a functional blueprint of microbial community metabolism that can be harnessed to engineer microbial consortia with defined emergent properties.
Taking into consideration the low sequence similarity to two different enzyme activities, and that sequence-based analysis only provides a presumptive compositional and functional blueprint of the gene analyzed, which in some cases may lead to erroneous assignment of substrate specificity [ 2], we assessed LipA for both lipase and carbohydrate esterase activity.
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Is the act of publishing a functional gun blueprint speech?
"They are working blueprints".
Therefore with BluePrint functional subtype IHC/FISH HER2+/HR+ patients are subdivided into BPLuminal with a poor response to NCT/trastuzumab and BPHER2 with a good response to NCT/trastuzumab.
These findings confirm the more accurate identification of molecular subgroups for treatment decision by the 80-gene BluePrint functional subtype classifier, which therefore may serve as a better guide for neoadjuvant treatment than standard, local IHC/FISH assay.
3 The objective of the current prospective NBRST study is to compare chemosensitivity as defined by pCR or endocrine sensitivity as defined by partial response (PR) for patients classified with the 80-gene BluePrint functional subtype profile to conventional IHC/FISH subtyping.
Emerging hypotheses capable of explaining such an investment posit that the brain's intrinsic functional architecture encodes a blueprint for its repertoire of responses to the external world.
We hope to unite the existing molecular and microscopic data on genome organization to get a holistic view of the nucleus, and propose a model, in which repeat repertoire together with scaffolding structures blueprint the functional nuclear architecture.
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