Sentence examples for functional blockade from inspiring English sources

Furthermore, recent preclinical studies as well as a clinical trial in diffuse‐type giant cell tumor patients provided evidence that the functional blockade of CSF1R impairs tumor‐promoting functions either by decreasing total TAM number or, alternatively, by reeducating TAMs (Pyonteck et al, 2013; Ries et al, 2014).

Functional blockade of these interactions enables increased effector T cell function during viral infection [19], in contrast, in models of CNS autoimmunity, these interactions are reported to dampen autoreactive T cell responses protecting the CNS [15], [16].

Early prefrontal functional blockade in rats results in schizophrenia-related anomalies in behavior and dopamine.

In the first (pre-exposure) session, functional blockade of the left SUB was achieved by local microinjection of tetrodotoxin (TTX).

To determine whether levobupivacaine produces a more potent and longer lasting peripheral nerve block than ropivacaine, we compared functional blockade of sciatic nerve in the rat at several doses with these 2 agents.

Binding of a chicken anti-fibrinogen antibody to platelets, indicating the level of functional blockade of GP IIb/IIIa, was inversely correlated with the binding of abciximab (r=-0.72, P:<0.0001).

These tumours are less hypoxic, owing to a more functional vasculature, and blockade of Dll4 signalling in these tumours leads to reduced therapy resistance (Li et al, 2011).

While these strategies could lead to global IFN-I blockade, functional inhibition of pDCs by 24F4A is expected to dampen pDC-derived IFN-I during disease, while preserving the protective IFN-I response to viruses in other immune and stromal cells (Swiecki & Colonna, 2010; Wang et al, 2012) which could be a safer therapeutic approach.

We also investigated the functional relevance of HMGCLL1 blockade with respect to response to TKI therapy and showed that small interfering RNA mediated blockade of HMGCLL1 isoform 3 results in significant decrease in viability of BCR-ABL1-positive cells including K562, CML-T1 or BaF3 cell lines with or without ABL1 kinase domain mutations such as T315I mutation.

The first structure of a sea anemone potassium channel toxin reveals how a novel structural scaffold can be used to present key functional groups for channel blockade.

In additional experiments, we also assessed the functional impact of JNK blockade on probiotic sonicates-induced LPMC apoptosis.