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pDC-primed central/effector memory antitumor T cells were highly functional as indicated by the specific IFNγ secretion and membrane CD107 expression upon stimulation.
This construct is functional as indicated by the fact that SWR1-TAP displayed the same resistance to HU as the wild type (Figure 6A).
Both CD4+ and CD8+ human T cell subsets as well as human B cells are highly functional as indicated by their ability to secrete human cytokines, reconstitute serum levels of human IgM, IgG, IgA, and IgE, and elicit specific IgG antibodies upon vaccination.
The increased Cx43 was functional as indicated by gap junctional intercellular communication among the resistant GBM cells.
TJ were functional as indicated by the establishment of an epithelial barrier nonpermeable to ruthenium red or a biotin tracer.
In the case of C. thermocellum fermentations of dilute acid pretreated feedstock, the cellulosome and/or free carbohydrolases appear functional, as indicated by high levels of liberated unfermented glucose and cellobiose in the fermentation broth.
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Therefore, the sequence variation should be partly responsible for their functional diversification, as indicated by the functional studies of OsNIP2 1 and OsNIP2 2 [ 10, 11, 13].
Predictive indices, developed to improve estimates of shorter survival, have included factors such as: falling functional status, as indicated by the Karnofsky or Bartell index [ 7], asthenia [ 8], weight loss, cognitive failure, dysphagia [ 9], high total white blood cell count, low lymphocyte percentage and low pseudocholinesterase [ 10].
However, in spite of the high window modularity peak (followed by a valley), we could not find a GO term or KEGG pathway that would also have its most representative peak in this region, as indicated by a functional annotation analysis using David Functional tools.
When joint equalization and decoding is performed, the equalizer, deinterleaver, and decoder are replaced by one functional block, as indicated by the dashed line around these functional blocks.
A second region is on chromosome 12q21 (spanning 9.36 Mb) and contains 37 genes including 9 genes for hypothetical or unknown function proteins; 2 genes of muscle development functional module as indicated by Gene Ontology (MYF5 and MYF6); CARthatthat is involved in muscle and skeletal development [ 41]; and synaptic transmission genes (NTS [ 42], SYT1 [ 43] and LIN7A/ Veli [ 44]).
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