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They're elegant, functional and robust: just as well-designed chairs should be.
The first generation of plant genome-scale metabolic reconstructions have proven surprisingly functional and robust as well as capable of predicting many observed complex phenotypes.
Building functional and robust scaffolds for engineered biological tissue requires a nanoscale mechanistic understanding of how cells use the scaffold for their growth and development.
A goal of systems biology is the generation of a coherent understanding of the mechanisms of how the integration of various components generates functional and robust systems in living organisms [1] [3].
Nonetheless, it is at present difficult to express functional and robust nAChRs consisting of only insect receptor subunits including those of the silkworm in heterologous cells, which should be resolved primarily.
While most of the TetR homologues could be systematically converted into both repressors and activators, for some only a single variant was found to be both functional and robust (BM3R1R, ButRA, and IcaRA).
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One of our main goals with SylViA is to develop a fully functional, usable, and robust application in hopes that it can be deployed and become part of every day life at SIMS, in the spirit of eDecisions.
Diastereomer 25 had high H3R binding affinity, excellent selectivity, displayed potent H3R functional antagonism and robust wake-promoting activity in vivo, and showed acceptable pharmacokinetic and pharmaceutical profiles for potential further development.
Hopefully, several studies witness the constant extension of the toolbox available to engineer a fully functional, contractile, and robust cardiac tissue using different combinations of cells, template bioscaffolds, and biophysical stimuli obtained by the use of specific bioreactors.
Thus understanding how genes, proteins, and small molecules interact to form the functional modules and robust systems has become one of the major challenges in systems biology in recent years.
Intracorporeal orthotopic neobladder (iONB) creation following robotic radical cystectomy is an emerging procedure and robust functional data are required.
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