At those loci, we identify candidate genes which, when rendered non-functional, alter those very demographic properties, and in turn, we identify candidate coding or regulatory variants that alter protein structure or gene expression, respectively, being prospective contributors to the variation in phenotype.
Aging is invariably associated with alterations of the hematopoietic stem cell (HSC) compartment, including loss of functional capacity, altered clonal composition, and changes in lineage contribution.
They may therefore be indirect targets or possess functional but altered PHO boxes.
To extrapolate major cellular functional networks altered in HU-treated NSCs, we performed IPA pathway analysis.
To analyze this in more detail, we tested if the functional groups altered in PDX models were similarly altered in metastases (compared with primary tumors).
Functional limitations, altered cardiac autonomic activity, and psychological distress are known disorders in patients with liver cirrhosis, relating to increased morbidity and mortality.
Downregulation of HIF-1α by overexpression of functional PHD2 altered the cancer cell phenotype and led to the occurrence of senescence markers (Kato et al. 2006).
Resting-state functional MRI (rs-fMRI) demonstrated altered functional connectivity was revealed in MOH, and suggested that MOH is associated with intrinsic brain network changes rather with macrostructural changes [23].
A limited number of functional imaging studies have reported altered functional neuronal activity of central motor regions [13] [16].
Functional divergence analysis revealed that altered functional constraints have occurred at specific amino acid positions after diversification of the paralogues.
