Sentence examples for functional abrogation from inspiring English sources

Most studies have shown that the intracellular trafficking [19], [29] and function [32], [33] of the transgene products are not affected by the 2A fusion, but mistargetting [34] and functional abrogation [35] of transgene products caused by such fusion have also been reported.

When they remain, functional abrogation of apoptosis is not an essential cause.

Thus, the high antileukemic potential of PFT-μ in combination with 17-AAG or SAHA might be explained by the functional abrogation of HSP70 upregulation in response to these specific drugs.

Thus, functional abrogation of the HSP70 response induced by HSP90 and histone deacetylase inhibitors may explain the remarkable antiproliferative effects of PFT-μ in combination with SAHA and especially with 17-AAG.

Indeed, functional abrogation of Daam1a markedly disrupts the formation of dendritic processes examined in single habenular neurons, also leading to an incomplete and less complex pattern of axonal terminals in the IPN.

(33, 34) It seems likely that disruptive mutations lead directly to the acquisition of malignant phenotype, whereas non-disruptive mutations, in concert with other events targeting the p53 pathway such as transcriptionally active HPV, might produce a synergistic effect of p53 functional abrogation.

They also indicate that the abrogation of functional Tcf7l2 has similar phenotypic consequences on both the left and right sides (parapineal independent elaboration of dHbl character), although the phenotype is only obvious on the right.

SNPinfo, is a web tool which offers the calculation of LD between query SNPs and GWAS SNPs in addition to functional prediction of these SNPs for abrogation or creation of potential MRESS [ 50].

It is possible that more complete abrogation of Foxh1 function in MZ eomesa mutants would reveal further functional relationships and attempts to generate double maternal zygotic mutants for Eomesa and Foxh1 are ongoing.

By contrast, no suppression of sae2∆ camptothecin hypersensitivity was observed by mutating His37 to Ala (mre11-H37A; Fig 2G), suggesting that the effects of the mre11 SUPsae2 ∆ alleles were not mediated by the abrogation of a specific function of His37 but more likely reflected functional alteration through introducing bulky amino acid side chains.

Although Chresta et al (1996) postulated that a hypersensitivity of human TGCT to drug-dependent apoptosis may also be associated with functional p53, Burger et al (1999) showed that abrogation of the p53 function does not affect the hypersensitivity of human TGCT cell lines to chemotherapy.