Sentence examples for functional aberration from inspiring English sources

Moreover, in PVN, for the stress-induced expression changes of hormonal genes, Crh and Oxt, Per1 mutant mice also exhibited significant differences from all other genotypes, suggesting that the lack of Per1 could lead to a functional aberration of hormonal system in PVN, further produce the effects on stress-induced grooming behavior and analgesia.

The reasons for the functional aberration of P53 in melanoma described in the current study are unclear.

Loss of cell cycle control through the structural or functional aberration of checkpoint genes and their products is a potentially important process in carcinogenesis.

Dysregulation of apoptosis results in structural deformities as well as functional aberration of the CNS, which accentuates the importance of PCD for the CNS development (Kuida et al., 1998; Tan et al., 2011).

In this study, we have examined the mRNA expression profile of known P53 target genes and regulators in a large number of melanoma metastases and cultured melanoma cell lines compared to normal melanocytes and fibroblasts to provide a global assessment of P53 functional aberration in melanoma.

Like other lymphoid cancers, CLL pathogenesis appears to be driven both by functional aberrations in immune function (Stevenson et al. 1998) and by somatic mutations, some of which may be a consequence of environmental exposures (Magrath 1992).

Other tests, including general health screen, sensorimotor functioning and gating, anxiety, social behaviour, learning and memory did not show any functional aberrations in Kv10.1 null mice.

This practice has provided only limited insight into functional aberrations and has failed to provided information necessary for disease classification based on pathophysiology.

Recent work has found that four independent gene rearrangements, all previously implicated in ASD, induce the same morphological and functional aberrations in the large dense core granules of platelets [149].

At the synapse level, we demonstrated both morphological and functional aberrations in mouse and Drosophila models.

A common strategy to distinguish functional aberrations from passengers is to identify those aberrations that are recurrent across multiple samples.