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Nevertheless, 8 accessions had GSH although OsC1 function was predicted to be normal.
Further, LILRA3 is the only non-membrane-bound LILR, and its function was predicted to be antagonistic with HLA-binding Group 1 LILRs [23].
Function was predicted to a 'hypothetical protein' if the aligned homologs had definite function which occurred more than five times with sequence alignment coverage >60%, sequence identity ≥40% and E value <1e-10.
Although the expression levels of TP53 was not significantly (NS) changed by GN-25 treatment in HMLE-SNAIL cells, its function was predicted to be inhibited in untreated HMLE-SNAIL cells, but activated by GN-25 treatment.
Interestingly, as shown by the z-score heatmaps (Supplementary Figure 6B), Cellular Movement and Cellular Growth and Proliferation functions were predicted to be decreased, whereas Cell Death function was predicted to be increased in CHKA-silenced cells as compared with their control.
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A function is predicted to be increased if the z-score is ≥2 and decreased if the z-score is less than or equal to −2.
Elevated MDM2 function is predicted to keep basal p53 activity low.
In addition to claudin-15 being crucial for ion transport function, more than 39 gene transcripts directly associated with ion transport function were predicted to be significantly reduced in diseased Hnf4α colon null mice (Table S4).
Through pressure-diuresis, normal kidney function is predicted to be able to partially ameliorate the effects of arterial stiffening on blood pressure.
Quite a few of the proteins of unknown function are predicted to be lipid-anchored and therefore may represent substrate-binding proteins of uncharacterized transporters.
As for example, the MYB-like transcription factors CCA1 and LHY, thought core for normal clock function, are predicted to drive output regulation [ 10, 8].
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