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To optimize performance given the relatively high number of dimensions in our grid searches (Additional file 1: Table S1), we used a grid that dynamically self-refined around the parameter regions in which the objective function was lowest.
The median difference between measured CrCl and the prediction method of excretory kidney function was lowest for the BCM based model mCrCl (bias = 0, absolute bias = 4.4, IQR = 7.9 mL/min/1.73 m).
The concentration of transforming growth factor- β (TGF- β), another key cytokine involved in CD4+Foxp3+ Treg function, was lowest in the peritoneal fluid from healthy controls, elevated in women with early stage endometriosis and highest in women with advanced stages of endometriosis.
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Kaplan-Meier analysis demonstrated that higher platelet function was associated with a mortality of 10%, while mortality was 40% when platelet function was low (collagen-test; P = 0.002).
The pilot study revealed that although 75% of patients owned mobile phones, use of the text messaging function was low, possibly because of relatively low literacy rates.
In the CONTRAST study, ß2-m decreased significantly in the HDF arm, especially in cases when residual kidney function was low [ 2].
When CYP3A4 function was low or inhibited by other drugs that inhibit CYP3A4, gefitinib metabolism that involves the formation of O-desmethyl-gefitinib and is determined by the CYP2D6 enzyme expressed in the liver was increased marginally [ 15].
Conversely, waist circumference is recorded in one in six women only, despite the data showing one in two women having a BMI of over 30 and recording of renal function was low.
In the three short-term trials, paliperidone appears to lead to a dose-dependent elevation in prolactin, although symptomatic hyperprolactemia (including galactorrhea, gynecomastia, amenorrhea, anorgasmia, and abnormal sexual function) was low (eight patients overall).
Enthusiasm from patients and clinicians for HealthSpace's secure messaging function was low, although a few patients who appeared to have high IT literacy found it both useful and easy to use.
Fasting insulin and estimated β-cell function were lowest and fasting and postload glucose were highest in African Caribbeans who had development of diabetes (Table 1).
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CEO of Professional Science Editing for Scientists @ prosciediting.com