Investors who traffic in JGBs have remarked that the market now functions very poorly, since so much of the market is held by the BOJ.
Unfortunately, fitness landscapes that are relevant to the evolution of complex biological functions are very poorly known.
Strong memories linger of the calamitous debut of HealthCare.gov on Oct. 1, 2013, when the balky system couldn't function, and worked very poorly for two months before a desperate overhaul by federal officials got the website working well enough to enroll more than 8 million customers by early April.
Finally we identified as novel Bc-xL interacting proteins a group of factors either with unknown or very poorly described function (Table 1).
The vast majority of genes in humans and other organisms undergo alternative splicing, yet the biological function of splice variants is still very poorly understood in large part because of the lack of simple tools that can map the expression profiles and patterns of these variants with high sensitivity.
HD-PTP, a Bro1 domain-containing protein, essential for early embryo development [8], has very poorly understood functions.
"These multi-symptomatic disorders caused by a defect in cilium function are really things we understand very poorly," Nachury says in the video above.
There is evidence that interactions between the antibody and the tissue might influence the outcome of the assay: p53 can be modified by phosphorylation (or acetylation/ubiquitination) at several sites, and the consequences of such phosphorylation for p53 function and epitope masking are still very poorly understood.
However, ecosystem structure and function at the deep seafloor have historically been very poorly studied because of the size and remoteness of the abyss.
The regulatory mechanisms underlying alternative splicing, as well as the biological significance and function of individual gene splice variants are, however, still very poorly understood (4).
