In mutation and knockout models of the voltage-gated sodium channels, perturbation of channel function during development impairs nervous system structure and function, underlining the importance of these channels in neurodevelopment.
Co-stimulation with exogenous ADP could partially rescue platelet function, underlining the essential role of ADP in driving the positive feedback loop and thus the platelet primary haemostatic response [13].
The finding of an increased rate of mutations in genes involved in RTK function underlines the importance of these signaling networks in the pathogenesis of MM, and should stimulate efforts to interfere with these signaling events therapeutically.
Consistent with the above, obesity-resistant rats have increased levels of SPA in the setting of increased activity of orexin A. Another fundamental function of orexin is the modulation of sleep, a function underlined by the neuroanatomical connections between the endogenous clock, the suprachiasmatic nucleus, and orexin cell bodies.
As mentioned, it is necessary to note that no causal direction between ADHD, anxiety, and depressive disorders can be stated, but the interrelation of these areas of psychosocial functioning underlines the need for an early intervention [ 60].
Thus, 53 genes in profiles "Pup", "Bdown" and "PupBdown", which tentatively contain the "permissive genes" were chosen as "key regulatory" genes and, among them, 29 genes with known functions (underlined in Figure 6 middle) are involved in immune response, signal transduction and so on.
The objective of this chapter is to provide a comprehensive overview of robotic approaches for the rehabilitation of hand function and underline their potential to complement conventional rehabilitation.
Non-specific Cre activity within these regulatory cells or integration of the transgene in a site important for their differentiation or function may underline the defect.
The role of MAPKs in mitochondrial function is underlined.
The tight regulation of PI metabolism and its critical impact on cellular function clearly underlines the importance of these compositional changes.
The bluntness of IQ tests to measure cognitive function is underlined by a study on five children who underwent left temporal lobectomy for epilepsy.
