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White matter hyperintensity did not correlate with the ADAS-Cog, MMSE or Auditory Verbal Learning Test, but did correlate with domains measures for language (Boston naming) and executive function (Trails B).
We also assessed patient participants' demographic characteristics; health literacy (Rapid Estimate of Adult Literacy in Medicine) [ 29]; numeracy level (Risk Numeracy) [ 30]; cognitive function (Trails B) [ 31]; and knowledge and awareness of kidney disease [ 7].
Subjects underwent a battery of 5 balance tests on the Neurocom posture platform, were tested for a number of possible confounders: Parkinson's severity (motor UPDRS), cognitive function (trails A & B, MMSE, verbal fluency, and clock draw), dyskinesias (mAIMS), and had serum drawn for vitamin D levels.
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Participants were screened for psychopathology (General Health Questionnaire-28) [ 36] and adequate cognitive function (Trail Making Test) [ 35].
However, all raised important questions about the relationship(s) between blebbing, RhoA signaling, mDia1 function, trailing uropod formation/function and entosis.
Baseline assessment included measures of verbal learning (Hopkins Verbal Learning Test-Revised), executive function (Trail-Making Tests A and B; Digit Span), visual memory (Rey-Osterrieth Complex Figure Test), and MMSE.
In addition to a possible TRAIL-sequestering function, TRAIL-R4 might impair TRAIL-induced apoptosis by forming inactive hetero-complexes with TRAIL-R2, and/or by triggering anti-apoptotic signaling pathways such as NF- κB and PKB/AKT.
The cognitive domains that we studied were verbal memory (Wechsler Memory Scale Logical Memory), visual memory (Wechsler Memory Scale Visual Reproduction), and executive function (Trail Making Tests A & B).
However, white matter hyperintensity correlated with domain scores for language (Boston naming) and executive functioning (Trails B).
But in patients with strong IoR, right hemisphere functions (trails, Mooney-faces, immediate and delayed visual recall) were related to HVA/5-HIAA.
Of interest in the present study are tests that measure general cognition (Mini-mental state exam (MMSE)), episodic memory (Logical memory story A delayed recall (LM-II), Rey auditory verbal learning test (AVLT)), language (Category fluency, Boston naming test (BNT)) and executive functioning (Trails A and B).
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