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It is thus possible that these strain-specific genetic modifiers may function to interfere with VHL downstream signaling, and compensate for the loss of pVHL.
Such genomic organization of host genes and antisense miRNAs might have a regulatory function to interfere with miRNA transcription, or might affect the host gene to influence mRNA splicing or to target sense mRNA.
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Dementia is an acquired syndrome of decline in memory and at least one other cognitive domain, such as language, visuo-spatial or executive function, sufficient to interfere with social or occupational functioning in an alert person (APA 1994).
Another option to inhibit TGF-β function is to interfere with postreceptor signaling.
Second, in axonal growth cones, Arp2/3 complex functions seem to interfere to some extend with the mere extension of the growth cone.
BCR-ABL bears dual functions to interfering with normal signal transduction.
Dementia is a disorder characterized by global impairment in cognition, social and occupational functioning severe enough to interfere with daily functioning and quality of life.
Inhibition of Complex I function is known to interfere with ATP generation, increase the production of reactive oxygen species and induce apoptosis (Li et al, 2003).
To that end, we established loss-of-function (LOF) and gain-of-function (GOF) strategies to interfere with sprout formation.
Therefore, we used both loss-of-function (LOF) and gain-of-function (GOF) strategies to interfere with angiogenesis and lymphangiogenesis.
Thus, we applied a function-blocking antibody to interfere with β1-integrin signaling and quantified the numbers of open and closed tubes after 2 days of culture.
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