Exact(37)
In particular, the acetoxymethyl substituent found at the 6-position of previously described active compounds can be replaced by an acetamidomethyl substituent without loss of potency; while the presence of an aryl ester function at the 3-position was preferred to a thioester or an amide function to induce marked biological activity.
E2F1 alone was not able to replace amino acids in its function to induce mTORC1 translocation.
The general dogma associated with HDACi is that they function to induce gene expression.
In vertebrates, FGF3 and FGF8 are expressed in pharyngeal endoderm where they function to induce cartilage.
Alternatively, it is possible that DAZL and PABP may cooperatively function to induce polyadenylation on tdrd7 and dazl mRNAs.
Many kinds of anticancer agents function to induce apoptosis of cancer cells which is characterized by caspase-3 and PARP cleavage.
Similar(23)
To test whether Delg is functionally linked to any of these pathways, we used gain-of-function to induce overgrowth in clones in a wild type or a delg mutant background.
To more appropriately model this, we use kernel functions to induce time varying parameters as described in File S1.
Moreover, Lctbs rhamnosus, a member of another genus of probiotic bacteria, modulates DCs functions to induce a novel form of T-cell hyporesponsiveness [ 79].
The molecular weight of CD147 is highly variable (31 65 kDa) because of heterogeneous N-glycosylation, with the most highly glycosylated forms functioning to induce MMP production.
In yeast, the C-terminal TAR region of ATAF2 functioned to induce lacZ gene expression, confirming ATAF2's role as a transcriptional activator.
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