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As for function, this polymorphism was speculated to affect mRNA [ 39].
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While the biological function of this polymorphism is unclear, STin2.12 has been reported to possess greater transcriptional activity than STin2.10 [8].
The function of this polymorphism has not yet been determined; however, the substitution of a hydroxylic amino acid (Ser) for an acidic amino acid (Asn) may affect the activity of the enzyme [ 12].
Information on the function of this polymorphism or its potential biological interaction with TP53 is needed and may add information to optimise the treatment of patients with bladder cancer.
Elucidation of the function of this polymorphism will help us understand the pathogenesis of H. pylori-induced gastric cancer, which will lead to more effective means for the personalized prevention of gastric atrophy and subsequent gastric cancer in the near future.
No in vitro or in vivo information regarding any putative change in function associated with this polymorphism is available.
Although the role of GST τ is not known in arsenic metabolism, it is possible that GSTT1 may have a similar function or that this polymorphism is in linkage disequilibrium with another polymorphism responsible for this observed effect.
Patients who have the TC genotype have increased BSD and VAS scores in our study, which can result from different affected neurotransmitter functions both from this polymorphism and in pain transport.
XRCC3 Thr241Met gene polymorphism could be associated with impaired function of repair, because this polymorphism consisting of Met to Thr substitution might influence the enzyme's function by removing a phosphorylation site [ 28].
Using noninvasive neuroimaging techniques, including both positron emission tomography (PET) and functional magnetic resonance imaging (fMRI), previous studies have examined the effect of this polymorphism on brain function.
Further biochemical analyses are needed to explore the significance of this polymorphism for TS function.
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