Shown are key endothelial cell (EC) functions that are altered in inflammation or sepsis.
The neuropsychological tests were selected because they provide sensitive, clinically relevant measures of nervous system functions that are altered by aging and by damage to central dopamine processes.
Global gene expression analyses highlighted several major cellular functions that are altered in 4T1 cells in which NFAT1 expression is decreased.
For example, expression profiling of resistant and sensitive genotypes that have and have not been experimentally evolved could be used to find cellular functions that are altered by resistance mutations and adaptation, both independently and in combination.
We have characterized the rat TNBS model of IBD at the genomic level, obtaining novel data on individual genes, metabolic pathways and biological functions that are altered during colitis.
Other functions of genes that were altered included cellular adhesion, cell growth and survival, energy production, myogenic function, oxidative stress response, extracellular matrix proteins, and ubiquitin-mediated degradation.
Although there are likely other non-transcriptional functions of Rb that are altered by its hyperphosphorylation [27], it is generally thought that the transcriptional activation of new mRNA in late-G1 for E2F-regulated genes is critical in promoting the final progression into S-phase.
Liver transcripts that were found to be altered with WD feeding were subsequently entered into Ingenuity Pathway Analysis (Qiagen) to elucidate gene networks and/or biological functions within the liver that were altered.
Sub-functions of lipid metabolism that were altered during the cattle-specific response included uptake of arachidonic acid, metabolism of long chain fatty acid, internalization of cholesterol, transport and quantity of fatty acid [Additional file 4].
The kinetochore also provides a powerful signaling function that is able to alter the properties of the spindle checkpoint and initiate a signal transduction cascade that leads to inhibition of the anaphase promoting complex and cell cycle arrest.
