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These results point toward a pharmacological approach to modulating GPCR function that affects the formation of beta-arrestin-mediated signaling complexes.
Besides this essential role, recent studies have mentioned a unique function that affects brain function.
VEGF also has an indirect neuroprotective function that affects neuronal survival in critical conditions.
It is not known if the colour-vision of frogs, signals for changes in neuro-endocrine function that affects metamorphosis.
This event leads to a gain of function that affects the gene expression pattern and the behavior of hematopoietic progenitor cells by downregulating histone arginine methylation.
Taken together, all this data and the fact that the mutation is of the missense type suggest similar functional consequence of p.I107T, and the mechanism of disease causation should be considered as either loss or gain of function that affects calcium homeostasis within the photoreceptor outer segment.
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The first model assumes that pleiotropic functions act as a strong constraint because mutations result in concerted changes in gene function that affect all appendage types (dependent model).
In addition, the alterations in pulmonary function that affect absorption of gases and volatile compounds also will affect their excretion through the pulmonary route (Birnbaum 1991).
One of the most striking changes that occur during normal human aging is immunosenescence, a pro-gressive and generalized deterioration of immune functions that affects all cells and organs of the innate and adaptive immune systems.
Offspring are born with subtle changes in brain function that affect social behavior and cognition.
This may be especially true of measures of functional connectivity or coherence between brain areas, as these may most powerfully index differences in network function that affect psychopathology.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com