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In the current study, we demonstrate an automated optimization method based on the Levenberg-Marquardt algorithm for electron-optical systems, incorporating an adaptive merit function switching process that enhances minimization convergence.
Two additional models are included in the performed analysis: the "classical" SIR model and a SIR model assuming time-dependent transmission rate, which is considered to be a step function switching between two values at a given time.
A possible explanation for the more severe phenotype of the missense mutations is that these mutations result in a gain of function, switching the SMARCA2/4 proteins to a constantly "on" state.
The OPCs may also be able to sense the amount of PDGF-A by the "rheostat-like" PDGFRα function, switching downstream signaling from the PI3K pathway to PLC–γ under higher PDGF-A concentration [41].
We demonstrate a dose-dependent effect of Fgf10 on H-NH axons, its attractive function switching to repellant activity at high concentrations, suggesting a mechanism for the stalling of axons as they reach the NH.
Regarding frequency of dosing, in patients demonstrating a continuing decline in renal function, switching from bi-weekly dosing to weekly dosing of agalsidase alfa (0.2 mg/kg) has been found to improve eGFR, with the mean rate of change in eGFR slowing from -8.0 ml/min per 1.73 m/year to -3.3 ml/min per 1.73 m/year [ 69].
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But when an electron absorbs light, its wave function switches to a dumb-bell shape that pushes against the poles of the bubble but not against its equator.
* Environmentally friendly auto-standby function switches the units to standby mode when no input or usage is detected for over 60 minutes.
At an inflection point, a function switches from being a convex function to being a concave function or vice versa.
Additional conditional in vivo loss-of-function data will be required to clarify whether β-catenin function switches from CM proliferation-promoting in the embryo to hypertrophy-promoting in the adult.
All MS and MS/MS spectra were acquired with the Q2-pulsing function switched on, and optimized for enhanced transmission of ions in the MS (m/ z 400 1000) and MS/MS (m/ z 75 1300) mass ranges.
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