Together with protein modeling of FCA, which indicates that longer polyglutamine tracts could induce suboptimally mobile functional domains, we suggest that CAG expansions may form slightly deleterious alleles (with respect to protein function) that become fixed in founder populations.
Terms such as vestige, contrivance, oddity, and imperfection are special instances of evolutionary remnants that are especially compelling because we have evidence that function in a given case is suboptimally or inefficiently developed, consistent with DWM but inconsistent with Special Creation.
Interestingly, clinically relevant doses of chloroquine also inhibit lysosomal function, although at a slower rate and suboptimally [ 46].
With decreased lung ventilation and clearance function, the possibility of infection rises within the suboptimally aerated lung.
We rationally designed these disulfide bonds to manipulate RG13's allosteric regulation mechanism such that the gating had maltose and reducing agents as input signals, and the gates could be toggled between different gating functions using redox agents, although some gates performed suboptimally.
There are no attributes, just skills, which is good because attributes in this context wouldn't serve a purpose other than punish you for managing them suboptimally.
Also, the role of gemcitabine/cisplatin combination in the adjuvant setting in suboptimally resected patients should be further pursued.
To reduce the complexity of PTS-AIC, this paper proposes a suboptimal way, called particle swarm optimization (PSO), to choose the weighting factors suboptimally without much performance degradation.
However, analyses of routine data have shown that, in first-generation immigrants, this strategy works suboptimally compared with native Dutch TB patients [ 27, 28].
