Loci exhibiting deviation from expected Mendelian ratios in female-segregating populations but not in male-segregating populations thus exhibited female-function segregation distortion (fSD).
Together, these findings reveal a major role for Ubc9, and, by implication, for the SUMO pathway, in nuclear architecture and function, chromosome segregation, and embryonic viability in mammals.
Four phase diagrams as a function of segregation strength and blend composition are constructed to show the effects of compositional gradient.
Although CENP-T-W-S-X tetramers are critical for centromere function, chromosome segregation still occurs in CENP-S or CENP-X-deficient cells (Amano et al., 2009).
This family is composed of more than 40 genes involved in spindle assembly and function, chromosome segregation, mitotic checkpoint control and cytokinesis.
Among these are the three Aurora kinase family members, Aurora-A, -B and -C, implicated in the regulation of multiple aspects of the mitotic process including centrosome maturation and function, chromosome segregation and cytokinesis [ 5- 9].
Using these cells, it will be interesting to study the role of RAD51C R258H in HR-mediated DSBR, in the repair of ICLs, checkpoint function, chromosome segregation and genome maintenance.
Typically these functions include segregation, maintenance, and support of neurons, including clearance and release of extracellular glutamate [5], [6], scavenging of oxygen free radicals [7] and homeostatic maintenance of extracellular ionic environment and pH [8], [9] These functions provide metabolic substrates for neurons [10], and couple cerebral blood flow to neuronal activity [11].
In contrast to the chromosome segregation function, the role of Ark1 in promoting chromosome condensation is not shared by Sgo2 (Supplementary Figure S5).
Segregation entropies are determined and are found to be a linear function of the segregation internal energies for the same GB sites.
