It was found that an instantaneous objective function resulted in better predictions than a terminal-type objective function.
Loss of POFUT2 function resulted in a severe fitness cost, as demonstrated by an approximate 80% reduction in parasite liver load compared to NF54 parents (P = 0.0155 using the paired t-test; Fig. 3c).
Structure activity investigations of product-like dipeptide analogues lacking the C-terminal carbonyl function resulted in potent and selective dipeptidyl peptidase II (DPP II) inhibitors.
Finally, the decline in the photosynthetic function resulted in a biomass reduction of between 50 and 80% (for 600 and 5000 mg Cu kg−1, respectively).
Finally, to investigate whether the decreased presynaptic function resulted in reduced glutamate levels at the synapse we used γ-d-glutamylglycine (γ-DGG), a low-affinity competitive antagonist of the AMPARs, at a non-saturating concentration (0.5 mM) at which its potency depends on glutamate level26.
The optimum operational parameters that fulfill the requirements of the optimization function resulted in areal biomass productivity of 32.1 gdwm−2d−1 and areal lipid production of 198.4 gLipidm−2.
Rearrangements of helix αC, a key regulatory element of kinase function, resulted in an additional helical turn at the αC N terminus and a distortion of its C terminus, a movement hitherto unseen in protein kinases.
The cubic loss function resulted in slightly different ranking.
CP466722 inhibited cellular ATM-dependent phosphorylation events and disruption of ATM function resulted in characteristic cell cycle checkpoint defects.
The companding method of [24] was used, since this function resulted in robust quantization in our experiments.
However, the boot.sw98 function resulted in a homogeneous bootstrap for the Shephard distance functions, so Farrell efficiencies were re-calculated using the reciprocals of the Shephard efficiencies.
