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How the various intracellular and extracellular sensory elements control channel function remains unresolved.
However, whether urate per se is detrimental to renal function remains unresolved.
Sig proteins are located to the mastigonemes [ 40], but their function remains unresolved.
Many reports have shown the enhancement of ER function in a variety of human cancers, but the mechanism for the cancer cell-specific regulation of ER function remains unresolved.
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Although the human genome project has been completed for some time, the issue of the number of transcribed genes with identifiable biological functions remains unresolved.
The BOK-deficient mice have no readily discernible abnormalities, and its function therefore remains unresolved.
Thus, the issue of whether fungal proteins are diseases, or have evolved for some specific functions, still remains unresolved.
Although the biological function of the antigen remains unresolved, the antigen is essential for maintaining the proliferating state of cells [27].
In CLCs, function of CBS domain remains unresolved and controversial.
However, the relationship between the age of reaching infant developmental milestones and later intellectual function within the general population remains unresolved.
Although the issue of whether CFHR5 nephropathy results from a loss-of-function or a gain-of-function change in the CFHR5 protein remains unresolved, the normal circulating C3 levels in patients with the disease suggest that CFHR5 nephropathy results from complement dysregulation specifically at glomerular surfaces, as opposed to systemic activation of complement in the fluid phase (see Fig. 2).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com