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These results suggest that ER phosphorylation alters receptor function (promoter targeting, chromatin remodeling and transcriptional output) effecting changes that could lead to a more sensitive response to EGF stimuli, as reported for tamoxifen-resistant breast tumors [43], [44].
Relative promoter strengths (vmax values) were determined using the transfer function promoter plasmids.
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This widely used reporter gene's coding region is unlikely to contain functioning termination elements, and furthermore, also unlikely to contain functioning promoter elements that could contribute to background transcription.
Thus, a novel gain-of-function promoter mutation of CRH has been identified, and this provides insights into the regulation of this gene and raises the possibility that CRH promoter mutations may be a cause of CS in man.
No attention is paid to whether the pseudogene has a functioning promoter or not, as promoter regions are still poorly characterized.
The inferred GRN had a modular topology, comprising five communities of highly interconnected nodes, consisting of genes with different functions, promoter motifs, and physical location in the genome.
All humans have the CGB8 promoter haplotype c8-155C/-c8147del/c8-144C/c8-142A, which seems to provide the most optimally functioning promoter because CGB8 is responsible for up to 40% of hCG production in pregnancy (6).
It can also affect the relationship between function and promoter conservation, because promoter type depends on G+C%.
The quantitative behavior of the AND gate phenotype is studied both in numero and in vivo as a function of promoter topology.
Each vector varies in its antibiotic resistance cassette, mobilization function, and promoter used to express insert sequences.
Moreover, the function of promoter analysis resembles that of search.
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