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One of SPIRE's primary assets is combining the results with data on protein function, pathways and protein expression from model organisms.
Amphetamine exerts its behavioral effects by altering the use of monoamines as neuronal signals in the brain, primarily in catecholamine neurons in the reward and executive function pathways of the brain, collectively known as the mesocorticolimbic projection.
Another potential source of error comes from misspecification of immune function pathways.
However, antigen presentation/dendritic cell (DC) function pathways were not affected significantly during infection.
Intriguingly, the function, pathways, and targets affected by many of the miRNAs involved in nasopharyngeal tumorigenesis overlap.
Similarly, top molecular and cellular function pathways included cell cycle, gene expression, cell death, cellular growth and proliferation and cellular assembly and organization (p < 0.01 for all pathways).
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Such high-level questions include: detecting differential expression in treatment and control tissues, gene function, pathway analysis, and changes in gene expression over time.
Another critical commonly regulated pathway is LPS/IL-1 mediated inhibition of RXR function pathway.
LIPC, FASN, and APOB are primarily downstream genes of FXR/RXR signaling, which is also a part of LPS/IL-1mediated inhibition of RXR function pathway.
Three kinds of enrichment maps for function, pathway, and regulatory networks were generated for each tissue.
Within the immune function pathway, the most affected genes were related to the T cell receptor-mediated T cell activation pathways.
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