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This clustering mechanism, along with the mapping function paradigm, allows us to super-resolve patches with high-frequency components.
The chapter focuses on the example of a small self-cleaving RNA domain present in some plant viroids and virusoids, the hammerhead ribozyme, which serves as a primary example of the RNA structure function paradigm.
Thus, our identified gate plug mechanism is relevant for designing PSEN1 modulating therapies for treatment of Alzheimer's disease within both the amyloid/γ-secretase hypothesis and within the PSEN1 loss of function paradigm.
In principle, the selected utility function for elastic services has been designed following the Shannon like log-based function paradigm, indicating the maximum data rate under which a transmission can successfully take place for a network's spectral capacity under interference conditions.
For these structured proteins, the sequence → structure → function paradigm has become paramount.
The functional characterization of a protein from its sequence using in silico methods based on the 'sequence to structure to function' paradigm is contingent upon the availability of its 3D-structure.
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Although without stable 3D structures and in contradiction to the traditional sequence-structure-function paradigm, IDPs play a number of crucial functional roles in living organisms, especially in vital biological processes, such as signaling, recognition, and regulation [ 27, 31, 32].
WIP is predicted to be an intrinsically disordered protein, a class of polypeptides that are of great interest because they violate the traditional structure-function paradigm.
Of late there has been a considerable shift in the protein sequence-structure-function paradigm.
A second control ("control dataset 2") (Table S7) was constructed which was biased in favor of the conventional wisdom of the "structure-function" paradigm.
Large-scale disordered IR data will be helpful in reassessing the traditional structure-function paradigm (the lock-and-key hypothesis; [29], [31]).
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