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The changes in the optimization target or machine tool design are easily considered by modifying the cost function or component model, respectively.
GO slim analysis of the 62 iL3-up (two or more fold) clusters (Tables 1 and 3) showed that most clusters (71, 79 and 77%, respectively) could not be assigned to a process, function or component.
Secondly, as this was an unselected consecutive patient cohort, we did not adjust for primary diagnosis, ASA score, cognitive function, or component malposition which are also recognized risk factors for dislocation (Lewinnek et al. 1978, Fackler and Poss 1980, Jolles et al. 2002, Nishii et al. 2004, Hailer et al. 2012, Ravi et al. 2014).
Of the 37 L1-up (two or more fold) clusters (Tables 1 and 4) approximately half the clusters could not be assigned to a process, function or component (38, 65 and 43%, respectively), but the largest remaining categories were consistent with larval growth.
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For example, genes may be organized into predefined sets based on annotation for their participation in a Gene Ontology function, process, or component [ 18].
This qualifier is used to explicitly denote that the gene product is not associated with the function, process or component represented by the GO term.
To identify annotations that needed to be reviewed and updated, all literature-based annotations were compared with all InterPro-based computational predictions to generate pairs of literature-based and computational annotations when both types of annotation existed for a given gene and GO aspect (Function, Process or Component).
The remainder of the classifications belonged to a diversity of processes, functions or components with no clear, unifying theme.
Moreover, processes, functions or components that are unique to diseases, such as oncogenesis, are not included in GO because causing cancer is not the normal function of any gene.
In the future, data generated from studies utilizing in vitro organotypic model systems should be judged or scrutinized in light of a system's ability to maintain or exhibit certain biochemical properties at physiologic levels, not just as the presence or absence of key functions or components, which so often occurs today in published reports.
Thereby, genes are associated to hierarchically clustered, functional terms that describe the "biological process", "molecular function" or "cellular component" which have a unique identification number.
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