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Thus, the likely function of this transporter is to clear di- and tri-peptides from the CSF.
As indicated by numerous biochemical studies and the phenotype of Abca4 –/– mice, the main function of this transporter is to accelerate the clearance of all-trans-retinal from ROS/COS.
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Therefore, the signaling function of a transporter is very easily overlooked.
The function of the transporters is in most cases yet unknown, but they are often predicted to be multidrug transporter.
Indeed, the function of proton transporters is involved in the capacity for pH maintenance [ 9, 10].
Therefore, the development of molecules capable of antagonizing the functions of MATE transporters is urgent because of their clinical importance.
Therefore, further study of the physiological functions of ABC transporters is necessary.
However, much remains to be uncovered as the physiological functions of many transporters are still largely unknown.
The ZIFL family of transporters is also thought to function in the vacuole.
Homologs of these transporters were shown to support invasin-type functions in other microbes [ 45].
Probe substrates for, and inhibitors of, specific transporters are desired to evaluate quantitatively the in vivo functions of transporters in humans.
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