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Maintaining adequate perfusion to tissues is the primary function of the vascular system, and it is controlled by a balance between vasodilatation and vasoconstriction7.
Mechanosensation of blood flow is a crucial function of the vascular system.
However, drugs that interfere with the function of the vascular system may also cause sometimes severe undesired effects [ 3, 84].
Normal functions of the CNS rely critically on the proper structure and function of the vascular system.
This supports the concept that application of estrogen is beneficial in preserving the normal function of the vascular system [ 33, 34].
In addition, our data provide evidence that the function of the vascular system is also altered in the contralateral knee joint.
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Previous studies suggest that tetraspanins directly regulate the development and functioning of the vascular system and the pathogenesis of vascular diseases [ 45].
In conditions of rat brain focal ischemia, Semax influenced the expression of genes that promote the formation and functioning of the vascular system.
Here, we found changes in the expression levels of several genes involved in the functioning of the vascular system as a response to Semax administration.
Since pannexins are involved in intercellular communication that is essential for the functioning of the vascular system [ 1], the presence (or absence) of pannexins will affect blood flow regulation.
Thus, as demonstrated here, the action of Semax on the expression of genes that ensure the formation and functioning of the vascular system in ischemic conditions also uncovered its possible vascular and regenerative properties, in addition to its neuroprotective and vasoactive effects.
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