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The binding and thus function of the TEL-AML1 fusion protein has been proposed to be mediated through the Runt DNA-binding domain of the AML1 fusion part.
Our primary analysis will be chi-square to detect differences in the proportion of respondents who attended breast screening within 3 months of the reminder letter or call as a function of the 4 arms (control, TEL, TEL-SUPP or TEL-SUPP-AR).
Protect" is part of the "Telling Your Story" training program.
To analyze whether the function of RelB in TEL-JAK2-induced leukemogenesis reflected an intrinsic role in the hematopoietic compartment, we generated bone marrow radiation chimeric mice.
Despite the widespread application of the TEL, three related drawbacks must be mentioned.
Establishing micro-macro link Fig. 2 Overview of the TEL environment and local instructional theory.
Function of the enhancer.
This suggests that either gene up-regulation is an indirect process, dependent on the down-regulation of transcriptional repressors mediated by the TEL/AML1 fusion protein, or that the repressor function of the TEL/AML1 fusion protein is counterbalanced by the presence of a normal RUNX1 protein.
This is leading to a complex early homeostatic function of TEL-AML1 in our pre-disposition cell line model as well as its prevalence in TEL-AML1-positive leukemic patients.
Transiently transfected TEL-AML1 blocks AML1-dependent transcription of several promoters with requirement of both, the TEL and AML1 part of the fusion protein.
Contact: Kathleen Barrutia of the Collectors Councill; tel.
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