In Figure 2A, the normalized response time T ON / T0 to activation is plotted as a function of the repression level measured as p ss / p0, where p ss is the final steady-state protein concentration, while p0 is the steady-state protein concentration in absence of negative regulation.
In order to quantify the relative contribution of the down regulation of Ndt80 on late meiosis repression, we calculated the following: In which the weight (W) of the regulation through Ndt80 is a function of the repression seen in the mutant (Rmutant) and those seen in the wt (Rwt).
Ceramide is known to play important functional roles in the nucleus, such as the regulation of SP3-HDAC1 suppressor function for the repression of hTERT (Wooten-Blanks et al, 2007).
The Arabidopsis homolog of the LOB gene ASYMMETRIC LEAVES2 (AS2) was demonstrated to function in the repression of KNOX genes and in the specification of adaxial/abaxial organ polarity [ 90].
To obtain a better understanding of the regulatory network underlying RGL2 function in the repression of seed germination, we performed an ab initio promoter motif detection in promoters of differentially regulated genes.
Given that NF-κB dependent pro-survival genes, Bcl-2 and XIAP, were significantly repressed, while NF-κB dependent pro-death genes, TNFα and Fas Ligand, were induced in response to H2O2, we suggest that NF-κB mediates its pro- cell death function through the repression of pro-survival genes and induction of pro-death genes.
Lin28 proteins are oncogenes activated in cancer which function through the repression of the let-7 miRNA family.
These results indicate that the CRD has an important function in the repression of AR by sFRP1.
Over-expression studies have shown FLM to have a similar function in the repression of flowering as FLC.
How chromosomal regions come into association with the periphery has been the subject of some debate, but NPC proteins are certainly central to the picture; the basket proteins such as Nup60p, Mlp1p, and Mlp2p, and the mobile nucleoporin, Nup2p, function in the repression of the HMR locus and other subtelomeric genes (Galy et al. 2000; Feuerbach et al. 2002; Dilworth et al. 2005).
Both our study and that of Korkola et al. identified good outcome GCTs express gene sets involved in immune function and the repression of differentiation (such as POU5F1/OCT4), while poor outcome GCTs express genes involved in active differentiation (in particular, neuron differentiation) (Fig. 3) [ 52].
