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The next essential steps involve studies of protein-protein and protein-RNA interactions aimed at defining the architecture of the machineries, as well as analyses of the function of the machineries and their components in vivo.
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Interpreting the function of this machinery is complicated, however, since most of the protein components have dual roles in translation and in translation-dependent RNA quality control pathways.
Thus, CgB is not required for proper function of the exocytotic machinery.
Additionally, our data provide fundamental insights into the function of the MMR machinery.
Impaired function of the RNA machinery plays an important role in aging [ 46].
This caspase-mediated PARP1 inactivation suggests that blocking PARP1 activity is vital for the proper function of the apoptotic machinery by the ensuing DNA fragmentation [ 11].
Moreover, the localization of PIN1, PIN2 and the auxin influx carrier AUX1 was found to be dependent on the function of the ESCRT machinery [ 34].
The elucidation of the localisation and function of the UPS machinery in the growth cones came from Campbell and Holt (2001) (Fig. 1A).
The mice die within four weeks because of heart and lung failure, in agreement with an essential function of the CASA machinery in muscle maintenance.
ScaRNAs mediate posttranscriptional modifications of splicing RNAs, which occurs in Cajal bodies and is important for the function of the splicing machinery.
Plants have to cope with this dynamic light environment by strategies that involve changes in the composition and function of the photosynthetic machinery [ 24].
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